TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.

ABSTRACT: The innate immunity is critically important in protection against virus infections, and in the case of RNA viral infections, the signaling mechanisms that initiate robust protective innate immunity without triggering autoimmune inflammation remain incompletely defined. In this study, we found the E3 ligase TRIM29 was specifically expressed in poly I:C-stimulated human myeloid dendritic cells. The induced TRIM29 played a negative role in type I IFN production in response to poly I:C or dsRNA virus reovirus infection. Importantly, the challenge of wild-type mice with reovirus led to lethal infection. In contrast, deletion of TRIM29 protected the mice from this developing lethality. Additionally, TRIM29^-/- mice have lower titers of reovirus in the heart, intestine, spleen, liver, a

SUBMITTER: Xing J 

PROVIDER: S-EPMC6092021 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature