Intra-arterial Versus Intravenous Adoptive Cell Therapy in a Mouse Tumor Model.

ABSTRACT: Adoptive cell transfer therapy for cancer has existed for decades and is experiencing a resurgence in popularity that has been facilitated by improved methods of production, techniques for genetic modification, and host preconditioning. The trafficking of adoptively transferred lymphocytes and infiltration into the tumor microenvironment is sine qua non for successful tumor eradication; however, the paradox of extremely poor trafficking of lymphocytes into the tumor microenvironment raises the issue of how best to deliver these cells to optimize entry into tumor tissue. We examined the route of administration as a potential modifier of both trafficking and antitumor efficacy. Femoral artery cannulation and tail vein injection for the intra-arterial (IA) and IV delivery, respectively, were

SUBMITTER: Visioni A 

PROVIDER: S-EPMC6092084 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature