Procurement Biopsy Findings Versus Kidney Donor Risk Index for Predicting Renal Allograft Survival.

ABSTRACT:

Background

Efforts to maximize transplantation by matching organ quality to recipient longevity require reliable tools. The US kidney allocation system uses the Kidney Donor Risk Index (KDRI) for this purpose, and many centers additionally rely on donor biopsies. The Leuven score combines donor age with procurement histology (glomerulosclerosis and interstitial fibrosis/tubular atrophy) to predict allograft survival.

Methods

We compared KDRI with Leuven scores for associations with kidney discard, delayed graft function, and allograft function and survival. We used Cox, modified Poisson, and linear regression to calculate risks based on KDRI and (separately) Leuven scores, adjusting for important transplant and recipient variables.

Results

From 890 donors, 1729 kidney

SUBMITTER: Hall IE 

PROVIDER: S-EPMC6092182 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature