Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank.

ABSTRACT: Observational studies have shown consistently increased likelihood of dementia or mild cognitive impairment diagnoses in people with higher air pollution exposure history, but evidence has been less consistent for associations with cognitive test performance. We estimated the association between baseline neighbourhood-level exposure to airborne pollutants (particulate matter and nitrogen oxides) and (1) cognitive test performance at baseline and (2) cognitive score change between baseline and 2.8-year follow-up, in 86,759 middle- to older-aged adults from the UK Biobank general population cohort. Unadjusted regression analyses indicated small but consistent negative associations between air pollutant exposure and baseline cognitive performance. Following adjustment for a range of key confo

SUBMITTER: Cullen B 

PROVIDER: S-EPMC6092329 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature