Gene Ontology Enrichment Improves Performances of Functional Similarity of Genes.

ABSTRACT: There exists a plethora of measures to evaluate functional similarity (FS) between genes, which is a widely used in many bioinformatics applications including detecting molecular pathways, identifying co-expressed genes, predicting protein-protein interactions, and prioritization of disease genes. Measures of FS between genes are mostly derived from Information Contents (IC) of Gene Ontology (GO) terms annotating the genes. However, existing measures evaluating IC of terms based either on the representations of terms in the annotating corpus or on the knowledge embedded in the GO hierarchy do not consider the enrichment of GO terms by the querying pair of genes. The enrichment of a GO term by a pair of gene is dependent on whether the term is annotated by one gene (i.e., partial annotation

SUBMITTER: Liu W 

PROVIDER: S-EPMC6092333 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature