Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

ABSTRACT: Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1^∆/∆ mice are deaf, Tmc2^∆/∆ mice have normal hearing, and double homozygous Tmc1^∆/∆; Tmc2^∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatiotemporal expression patterns. Tmc1 expression is persistent in cochlear and vestibular hair cells, whereas Tmc2 expression is transient in cochlear hair cells but persistent in vestibular hair cells. On the basis of these findings, we hypothesized that persistent Tmc2 expression in mature cochlear hair cells could restore auditory function in Tmc1^∆/∆ mice. To express Tmc2 in mature cochlear hair cells, we generated a trans

SUBMITTER: Nakanishi H 

PROVIDER: S-EPMC6092339 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature