Oxidative stress decreases the redox ratio and folate content in the gut microbe, Enterococcus durans (MTCC 3031).

ABSTRACT: Gut microbiome plays an important role in determining the effectiveness of cancer therapy. The composition of the microbiome is crucial to maintain good digestive health in the host, and to prevent and treat colorectal cancers. Most cancer therapies employ oxidative stress, which disturbs the redox status of the cell, and consequently affect growth, reductive biosynthesis and cell death. Therefore, oxidative stress can undesirably affect the gut microbiome. Hence, it is important to understand the impact of oxidative stress on gut bacteria to devise effective treatment strategies. The current study induces oxidative stress in the model gut bacterium Enterococcus durans (MTCC 3031) with menadione and H₂O₂. Oxidative stress considerably decreased the redox ratio (NADPH/

SUBMITTER: Jose S 

PROVIDER: S-EPMC6092354 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature