A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

ABSTRACT: Atropisomers with a biaryl dihydronaphthopyranone structure, dinapinones A1 (DPA1) (M position) and A2 (DPA2) (P position), were isolated from the fungus culture broth of Talaromyces pinophilus FKI-3864 as inhibitors of [¹⁴C]neutral lipid ([¹⁴C]triacylglycerol (TG) and [¹⁴C]cholesteryl ester (CE)) synthesis from [¹⁴C]oleic acid in Chinese hamster ovary-K1 (CHO-K1) cells. DPA2 inhibited [¹⁴C]TG and [¹⁴C]CE synthesis (IC₅₀s_, 0.65 and 5.6 μM, respectively), but DPA1 had no inhibitory activity on [¹⁴C]TG and [¹⁴C]CE synthesis even at 12 μM. However, a 1:1 mixture of DPA1 and DPA2 (DPA_mix) had the most potent inhibitory activity on [¹⁴C]TG and [¹⁴C]CE sy

SUBMITTER: Kobayashi K 

PROVIDER: S-EPMC6092391 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature