Integrated imaging of [¹¹C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy ¹H-MRS in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To determine the relationship between brain tissue metabolites measured by in vivo magnetic resonance spectroscopy (¹H-MRS), and glial activation assessed with [¹¹C]-PBR28 uptake in people with amyotrophic lateral sclerosis (ALS).

Methods

Forty ALS participants were evaluated clinically using the revised ALS functional rating scale (ALSFRS-R) and upper motor neuron burden (UMNB). All participants underwent simultaneous brain [¹¹C]-PBR28 PET and MR imaging including diffusion tensor imaging to acquire fractional anisotropy (FA). [¹¹C]-PBR28 uptake was measured as standardized uptake values normalized by whole brain mean (SUVR). ¹H-MRS metabolite ratios (myo-inositol/creatine, mI/Cr; N-acetylasparta

SUBMITTER: Ratai EM 

PROVIDER: S-EPMC6092554 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature