Isolation of circulating tumor cells in a preclinical model of osteosarcoma: Effect of chemotherapy.

ABSTRACT: Osteosarcoma is a rare primary bone tumor, which mainly affects children and adolescents and has a poor prognosis, especially for patients with metastatic disease. A poor therapeutic response to the conventional chemotherapy is observed with the development of lung metastases, highlighting the need for improving the current regimens and the identification of early markers of the recurrent and metastatic disease. Circulating Tumour Cells (CTCs) play a key role in the metastatic process and could be powerful biomarkers of the progressive disease. The present study aimed to isolate CTCs by using a pre-clinical model of human osteosarcoma and to monitor their kinetic of release and their modulation by ifosfamide. CTCs were detectable into the bloodstream before any palpable primary tumors. Ifo

SUBMITTER: Chalopin A 

PROVIDER: S-EPMC6092555 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature