Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.

ABSTRACT: Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our understanding of the complex interactions among their respective disease pathways preclude successful treatment and prevention. The placenta has a key role in the pathogenesis of the terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension, and proteinuria. This sine qua non of preeclampsia may be triggered by distinct underlying mechanisms that occur at early stages of pregnancy and induce different phenotypes. To gain insights into these molecular pathways, we employed a systems biology approach and integrated different "omics," clinical, placental, and functional data from patients with distinct phenotypes of preeclampsia. First trime

SUBMITTER: Than NG 

PROVIDER: S-EPMC6092567 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature