Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila.

ABSTRACT: Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate differentiating offspring cells. Several chromatin modifiers have been identified as stemness factors in mammalian pluripotent stem cells, but whether these factors control stem cell polarity and asymmetric division has not been investigated so far. We addressed this question in Drosophila neural stem cells called neuroblasts. We identified the Tip60 chromatin remodeling complex and its interaction partner Myc as regulators of genes required for neuroblast maintenance. Knockdown of Tip60 complex members results in loss of cortical polarity, symmetric neuroblast division, and premature differentiation through nuclear entry of the transcription factor Prospero. We found

SUBMITTER: Rust K 

PROVIDER: S-EPMC6092623 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature