Occupational asthma risk from exposures to toluene diisocyanate: A review and risk assessment.

ABSTRACT: BACKGROUND:Toluene Diisocyanate (TDI) is a known respiratory sensitizer linked to occupational asthma (OA). To better manage worker risks, an appropriate characterization of the TDI-OA dose-risk relationship is needed. METHODS:The literature was reviewed for data suitable for dose-response modeling. Previous study data were fit to models to derive prospective occupational exposure limits (OELs), using benchmark dose (BMD) and low-dose extrapolation approaches. RESULTS:Data on eight TDI-exposed populations were suitable for analysis. There were 118 OA cases in a population contributing 13 590 person-years. The BMD-based OEL was 0.4 ppb. The OEL based on low-dose extrapolation to working lifetime extra risk of 1/1000 was 0.3 ppb. CONCLUSIONS:This study synthesized epidemiologic data to chara

SUBMITTER: Daniels RD 

PROVIDER: S-EPMC6092631 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature