Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment.

ABSTRACT: Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs) is crucial for the development of therapeutic strategies based on the stimulation of their endogenous regenerative potential in the damaged brain. We show that LeX^bright cells sorted from the adult mouse subventricular zone exhibit all the characteristic features of quiescent NSCs. Indeed, they constitute a subpopulation of slowly dividing cells that is able to enter the cell cycle to regenerate the irradiated niche. Comparative transcriptomic analyses showed that they express hallmarks of NSCs but display a distinct molecular signature from activated NSCs (LeX⁺EGFR⁺ cells). Particularly, numerous membrane receptors are expressed on quiescent NSCs. We further revealed

SUBMITTER: Morizur L 

PROVIDER: S-EPMC6092681 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature