Ligand-assisted palladium-catalyzed C-H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines.

ABSTRACT: The development of a ligand-assisted Pd-catalyzed C-H alkenylation of aliphatic amines is reported. Our studies indicated that an amino-acid-derived ligand renders the C-H bond activation step reversible and promotes the traditionally difficult alkenylation process. The C(sp³)-H alkenylation proceeds through a 5-membered-ring cyclopalladation pathway that allows access to complex aliphatic heterocycles that could be useful to practioners of synthetic and medicinal chemistry.

SUBMITTER: He C 

PROVIDER: S-EPMC6092717 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature