Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study.

ABSTRACT: Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function). The relation between infarct location and cognition was assessed in multivariate analyses at the voxel-l

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6092771 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature