Evaluating the gray and white matter energy budgets of human brain function.

ABSTRACT: The insatiable appetite for energy to support human brain function is mainly supplied by glucose oxidation (CMR_glc(ox)). But how much energy is consumed for signaling and nonsignaling processes in gray/white matter is highly debated. We examined this issue by combining metabolic measurements of gray/white matter and a theoretical calculation of bottom-up energy budget using biophysical properties of neuronal/glial cells in conjunction with species-exclusive electrophysiological and morphological data. We calculated a CMR_glc(ox)-derived budget and confirmed it with experimental results measured by PET, autoradiography, ¹³C-MRS, and electrophysiology. Several conserved principles were observed regarding the energy costs for brain's signaling and nonsignaling

SUBMITTER: Yu Y 

PROVIDER: S-EPMC6092772 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature