Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease.

ABSTRACT:

Background

Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cellular source we compared, in the rat model of adriamycin (ADR) nephropathy, the regenerative potential of human stromal cells of non-renal origin, such as bone marrow (bm) MSCs and umbilical cord (uc) MSCs, with that of newly discovered stromal cells of renal origin, the kidney perivascular cells (kPSCs) known to exhibit tissue-specific properties.

Methods

The therapeutic effect of repeated infusions of human bmMSCs, ucMSCs, kPSCs (1.5 × 10⁶ cells/rats) or conditioned medium from ucMSCs was studied in athymic rats with ADR-induced nephropathy (7.9 m

SUBMITTER: Rota C 

PROVIDER: S-EPMC6092807 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature