K_v1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4⁺ effector memory T cell response to TCR stimulation.

ABSTRACT:

Background

In T cells, the K_v1.3 and the K_Ca3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during T_EM cell activation, the number of K_v1.3 channels on the cell membrane dramatically increases. K_v1.3 blockade results in inhibition of Ca²⁺ signaling in T_EM cells, thus eliciting an immunomodulatory effect. Among the naturally occurring peptides, the Vm24 toxin from the Mexican scorpion Vaejovis mexicanus is the most potent and selective K_v1.3 channel blocker known, which makes it a promissory candidate for its use in the clinic. We have shown that addition of Vm24 to TCR-activated human T cells inhibits CD25 expression, cell proliferation and reduces delaye

SUBMITTER: Veytia-Bucheli JI 

PROVIDER: S-EPMC6092819 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature