Real-time monitoring of Pseudomonas aeruginosa biofilm formation on endotracheal tubes in vitro.

ABSTRACT:

Background

Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for both acute and chronic infections in humans. In particular, its ability to form biofilm, on biotic and abiotic surfaces, makes it particularly resistant to host's immune defenses and current antibiotic therapies as well. Innovative antimicrobial materials, like hydrogel, silver salts or nanoparticles have been used to cover new generation catheters with promising results. Nevertheless, biofilm remains a major health problem. For instance, biofilm produced onto endotracheal tubes (ETT) of ventilated patients plays a relevant role in the onset of ventilation-associated pneumonia. Most of our knowledge on Pseudomonas aeruginosa biofilm derives from in vitro studies carried out on abiotic surfaces,

SUBMITTER: Pericolini E 

PROVIDER: S-EPMC6092828 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature