Prognostic and clinicopathological value of Beclin-1 expression in hepatocellular carcinoma: a meta-analysis.

ABSTRACT:

Background

The abnormal expression of Beclin-1 has recently been investigated in a variety of tumors. However, previous studies have obtained contradicting results regarding the clinical and prognostic value of Beclin-1 in hepatocellular carcinoma (HCC). We performed a meta-analysis to clarify the prognostic value of Beclin-1 and its correlations with clinical pathological parameters in HCC.

Methods

Relevant studies were systematically retrieved from PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Wan Fang and Chinese VIP databases. We used the Newcastle-Ottawa scale (NOS) to estimate the quality of the involved studies.

Results

Ten eligible studies with 1086 HCC patients were included in this study. Our results showed that decreased Beclin-1 expressio

SUBMITTER: Qin Z 

PROVIDER: S-EPMC6092876 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature