Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis.

ABSTRACT: Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system. In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells. Of the 420 plant extracts screened, the extract of Angelica gigas Nakai (AGN) was the most effective in reducing cell viability of HeLa cells. Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract. Tre

SUBMITTER: Jeon YJ 

PROVIDER: S-EPMC6093040 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature