Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children.

ABSTRACT:

Background

In contrast to pediatric Crohn's disease (CD), little is known in pediatric ulcerative colitis (UC) about the relationship between disease phenotype and serologic reactivity to microbial and other antigens.

Aim

The aim of this study was to examine disease phenotype and serology in a well-characterized inception cohort of children newly diagnosed with UC during the PROTECT Study (Predicting Response to Standardized Pediatric Colitis Therapy).

Methods

Patients were recruited from 29 participating centers. Demographic, clinical, laboratory, and serologic (pANCA, ASCA IgA/IgG, Anti-CBir1, and Anti-OmpC) data were obtained from children 4-17 years old with UC.

Results

Sixty-five percent of the patients had positive serology for pANCA, with 62% less than 1

SUBMITTER: Spencer EA 

PROVIDER: S-EPMC6093192 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature