Kidney Function, Polypharmacy, and Potentially Inappropriate Medication Use in a Community-Based Cohort of Older Adults.

ABSTRACT:

Background

Chronic kidney disease (CKD) afflicts many older adults and increases the risk for medication-related adverse events.

Objective

The aim of this study was to assess the prevalence and associated morbidity and mortality of polypharmacy (use of several medications concurrently), and potentially inappropriate medication (PIM) use in older adults, looking for differences by CKD status.

Methods

We quantified medication and PIM use (from Beers criteria, the Screening Tool of Older People's Prescriptions, and Micromedex^®) by level of estimated glomerular filtration rate (eGFR) for participants aged 65 years or older attending a baseline study visit in the Atherosclerosis Risk in Communities study (n =6392). We used zero-inflated negative binomial and Cox

SUBMITTER: Secora A 

PROVIDER: S-EPMC6093216 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature