Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.

ABSTRACT: Adaptations and responses to stress conditions are fundamental processes that all cells must accomplish to maintain or restore cellular homeostasis. Cells have a plethora of response pathways to mitigate the effect of different environmental stressors. The transcriptional regulators transcription factor EB (TFEB) and transcription factor binding to IGHM enhancer 3 (TFE3) play a key role in the control of these stress pathways. Therefore, understanding their regulation under different stress conditions is of great interest. Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process. We found that the mechanism of arsenite-stimulated TFEB and TFE3 activa

SUBMITTER: Martina JA 

PROVIDER: S-EPMC6093222 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature