Delineating FtsQ-mediated regulation of cell division in Mycobacterium tuberculosis.

ABSTRACT: Identifying and characterizing the individual contributors to bacterial cellular elongation and division will improve our understanding of their impact on cell growth and division. Here, we delineated the role of ftsQ, a terminal gene of the highly conserved division cell wall (dcw) operon, in growth, survival, and cell length maintenance in the human pathogen Mycobacterium tuberculosis (Mtb). We found that FtsQ overexpression significantly increases the cell length and number of multiseptate cells. FtsQ depletion in Mtb resulted in cells that were shorter than WT cells during the initial growth stages (4 days after FtsQ depletion) but were longer than WT cells at later stages (10 days after FtsQ depletion) and compromised the survival in vitro and

SUBMITTER: Jain P 

PROVIDER: S-EPMC6093227 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature