TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2^R47H on murine myeloid cell function.

ABSTRACT: Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, supporting the hypothesis that TREM2 loss of function may exacerbate disease progression. However, a complete knockout of the TREM2 gene in different genetic models of neurodegenerative diseases has been reported to result in both protective and deleterious effects on disease-related end points and myeloid cell function. Here, we describe a Trem2^R47H transgenic mouse model and report that even in the absence of additional genetic perturbations, this variant clearly confers a loss of function on myeloid cells. The Trem

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC6093249 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature