Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study.

ABSTRACT: Among 365 Hertfordshire Cohort Study participants (aged 59-71 years at baseline), higher adiponectin and adiponectin to leptin ratios were associated with lower baseline lumbar spine and femoral neck bone mineral density (BMD). Lower IL-10 was associated with accelerated decline in lumbar spine BMD. This suggests that bone health can be influenced by changes in immune phenotype and alterations in adipokine homeostasis.

Introduction

The aim of this study was to examine the association between indices of inflammation and BMD in a population-based cohort of older adults in the UK.

Methods

Analyses were based on a sample of 194 men and 171 women of the Hertfordshire Cohort Study (community-living, older adults). Dual energy X-ray absorptiometry (DXA) was performed at the lumbar s

SUBMITTER: Fuggle NR 

PROVIDER: S-EPMC6093277 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature