Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women.

ABSTRACT: Genetic risk of low bone mineral density in women remains unclear. This study found that a large percentage of Caucasian women have a high genetic risk of osteoporosis, and genetic risk scores are significantly associated with BMD variation in a bone healthy sample of Caucasian women.

Introduction

We aimed to examine the distribution of risk alleles in an independent sample and to determine if such genetic components are associated with bone mineral density (BMD) variation in the sample.

Methods

Existing genotype data of 1205 women in the cross-sectional Genomic Wide Scans for Female Osteoporosis Gene Study (GWSFO) were analyzed. Multi-loci genetic risk scores (GRSs) based on 62 BMD-associated single nucleotide polymorphisms (SNPs) were calculated. Regression analysis was emp

SUBMITTER: Xiao X 

PROVIDER: S-EPMC6093295 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature