Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection.

ABSTRACT: HIV-1 causes premature aging in chronically infected patients. Despite effective anti-retroviral therapy, around 50% of patients suffer HIV-associated neurocognitive disorders (HAND), which likely potentiate aging-associated neurocognitive decline. Microglia support productive HIV-1 infection in the brain. Elevated markers of cellular senescence, including p53 and p21, have been detected in brain tissues from patients with HAND, but the potential for microglia senescence during HIV-1 infection has not been investigated. We hypothesized that HIV-1 can induce senescence in microglia. Primary human fetal microglia were exposed to single-round infectious HIV-1 pseudotypes or controls, and examined for markers of senescence. Post-infection, microglia had significantly elevated: senescence-assoc

SUBMITTER: Chen NC 

PROVIDER: S-EPMC6093403 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature