Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis.

ABSTRACT:

Background

The obesity-lung cancer association remains controversial. Concerns over confounding by smoking and reverse causation persist. The influence of obesity type and effect modifications by race/ethnicity and tumor histology are largely unexplored.

Methods

We examined associations of body mass index (BMI), waist circumference (WC), and waist-hip ratio (WHR) with lung cancer risk among 1.6 million Americans, Europeans, and Asians. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for potential confounders. Analyses for WC/WHR were further adjusted for BMI. The joint effect of BMI and WC/WHR was also evaluated.

Results

During an average 12-year follow-up, 23 732 incident lung cancer cases

SUBMITTER: Yu D 

PROVIDER: S-EPMC6093439 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature