Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131.

ABSTRACT: Background:Epidemiological studies point to the gut as a key reservoir of multidrug resistant Escherichia coli multilocus sequence type 131 (ST131), a globally dominant pathogenic clone causing urinary tract and bloodstream infections. Here we report a detailed investigation of its intestinal lifestyle. Methods:Clinical ST131 isolates and type 1 fimbriae null mutants were assessed for colonization of human intestinal epithelia and in mouse intestinal colonization models. Mouse gut tissue underwent histologic analysis for pathology and ST131 localization. Key findings were corroborated in mucus-producing human cell lines and intestinal biopsy specimens. Results:ST131 strains adhered to and invaded human intestinal epithelial cells more than probiotic and commensal strains. The reference ST1

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC6093498 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature