Automated quantification of low amplitude rhythmic contractions (LARC) during real-world urodynamics identifies a potential detrusor overactivity subgroup.

ABSTRACT:

Objectives

Detrusor overactivity (DO) is characterized by non-voiding detrusor smooth muscle contractions during the bladder filling phase and often contributes to overactive bladder. In some patients DO is observed as isolated or sporadic contractions, while in others DO is manifested as low amplitude rhythmic contractions (LARC). The aim of this study was to develop an objective method to quantify LARC frequencies and amplitudes in urodynamic studies (UDS) and identify a subgroup DO of patients with LARC.

Methods

An automated Fast Fourier Transform (FFT) algorithm was developed to analyze a 205-second region of interest of retrospectively collected "real-world" UDS ending 30 seconds before voiding. The algorithm was designed to identify the three largest rhythmic amplitude

SUBMITTER: Cullingsworth ZE 

PROVIDER: S-EPMC6093663 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature