Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling.

ABSTRACT: Despite the prevalence and high heritability of Attention-Deficit/Hyperactivity Disorder (ADHD), genetic etiology remains elusive. Clinical evidence points in part to reduced function of the striatum, but which specific genes are differentially expressed and how they sculpt striatal physiology to predispose ADHD are not well understood. As an exploratory tool, a polygenic mouse model of ADHD was recently developed through selective breeding for high home cage activity. Relative to the Control line, the High-Active line displays hyperactivity and motor impulsivity which are ameliorated with amphetamine. This study compared gene expression in the striatum between Control and High-Active mice to develop a coherent hypothesis for how genes might affect striatal physiology and predispose ADHD-l

SUBMITTER: Sorokina AM 

PROVIDER: S-EPMC6093675 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature