CXCR5 and ICOS expression identifies a CD8 T-cell subset with T_FH features in Hodgkin lymphomas.

ABSTRACT: A better characterization of T-cell subsets in the microenvironment of classical Hodgkin lymphoma (cHL) would help to develop immunotherapies. Using multicolor flow cytometry, we identified in 6 of 43 cHL tissue samples a previously unrecognized subset of CD8 T cells coexpressing CXCR5 and inducible T-cell costimulator (ICOS) molecules (CD8_CXCR5+ICOS+). These cells shared phenotypic features with follicular helper T (T_FH) cells including low CCR7 expression together with high expression of B-cell lymphoma-6, programmed cell death 1, B and T lymphocyte attenuator, CD200, and OX40. They had deficient cytotoxicity, low interferon-γ secretion, and common functional properties with intratumoral CD4⁺ T_FH cells, such as production of interleukin-4 (IL-4

SUBMITTER: Le KS 

PROVIDER: S-EPMC6093730 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature