Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors.

ABSTRACT: Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation, and chemotherapy. GBM tumors are highly heterogeneous, and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (temozolomide [TMZ]) while retaining radioactive isotopes agents (iodine, [¹³¹I]) was used as a vehicle for localized radiation and chemotherapy, within the surgical cavity. Release from hydrogels loaded with TMZ or ¹³¹I was characterized in vitro and in vivo and their efficacy on tumor progression and survival on GBM tumors was also measured. The in vitro release of ¹³¹I was negligible

SUBMITTER: Puente P 

PROVIDER: S-EPMC6093750 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature