Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration.

ABSTRACT:

Background

The symptoms of major depressive disorder (MDD) are rapidly alleviated by administration of a single dose of the glutamatergic modulator ketamine. However, few studies have investigated the potential sustained neural effects of this agent beyond immediate infusion. This study used functional magnetic resonance imaging to examine the effect of a single ketamine infusion on the resting state default mode network (DMN) at 2 and 10 days after a single ketamine infusion in unmedicated subjects with MDD as well as healthy control subjects (HCs).

Methods

Data were drawn from a double-blind, placebo-controlled crossover study of 58 participants (33 with MDD and 25 HCs) who received an intravenous infusion of either ketamine hydrochloride (0.5 mg/kg) or placebo on 2 separa

SUBMITTER: Evans JW 

PROVIDER: S-EPMC6093808 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature