CCL2 and CXCL10 are associated with poor outcome after intracerebral hemorrhage.

ABSTRACT:

Objective

Intracerebral hemorrhage carries a high mortality and survivors are frequently left with significant disability. Immunological mechanisms may play an important role in hemorrhage-induced brain injury, however, research linking these mechanisms with clinical outcome remains limited. We aim to identify serum inflammatory mediators that are associated with outcome after intracerebral hemorrhage in order to translate data from experimental models to a patient cohort and identify potential targets worthy of reverse translation.

Methods

A prospective cohort study at two comprehensive stroke centers enrolled patients with spontaneous intracerebral hemorrhage. Peripheral blood was collected at 6, 24, and 72 h from onset. Functional outcome was assessed at 90 days using the

SUBMITTER: Landreneau MJ 

PROVIDER: S-EPMC6093844 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature