Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

ABSTRACT: Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance. Here, an individual with locked-in syndrome due to brain stem stroke and an individual with tetraplegia secondary to amyotrophic lateral sclerosis (ALS) used a simple communication BCI based on intracortical local field potentials (LFPs) for 76 and 138 days, respectively, without recalibration and without significant loss of perfor

SUBMITTER: Milekovic T 

PROVIDER: S-EPMC6093965 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature