Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Cancer.

ABSTRACT:

Background

Ibrutinib is a Bruton tyrosine kinase inhibitor that is used for the treatment of lymphoid cancers, including chronic lymphocytic leukemia, Waldenström macroglobulinemia, and mantle cell lymphoma. Several case series have described opportunistic infections among ibrutinib recipients, but the full extent of these infections is unknown. We sought to determine the spectrum of serious infections associated with ibrutinib treatment.

Methods

We reviewed the electronic medical records of patients with lymphoid cancer at Memorial Sloan Kettering Cancer Center who received ibrutinib during a 5-year period from 1 January 2012 to 31 December 2016. Serious infections were identified by review of the relevant microbiology, clinical laboratory, and radiology data. Risk factors

SUBMITTER: Varughese T 

PROVIDER: S-EPMC6093991 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature