RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.

ABSTRACT: Seventy percent of people infected with hepatitis C virus (HCV) will suffer chronic infection, putting them at risk for liver disease, including hepatocellular carcinoma. The full range of mechanisms that render some people more susceptible to chronic infection and liver disease is still being elucidated. XRN exonucleases can restrict HCV replication and may help to resolve HCV infections. However, it is unknown how 5' triphosphorylated HCV transcripts, primary products of the viral polymerase, become susceptible to attack by 5' monophosphate-specific XRNs. Here, we show that the 5' RNA triphosphatase DUSP11 acts on HCV transcripts, rendering them susceptible to XRN-mediated attack. Cells lacking DUSP11 show substantially enhanced HCV replication, and this effect is diminished when XRN exp

SUBMITTER: Kincaid RP 

PROVIDER: S-EPMC6094126 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature