Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans.

ABSTRACT: Sphingolipids are bio-active metabolites that show structural diversity among eukaryotes. They are essential for growth of all eukaryotic cells but when produced in an uncontrolled manner can lead to cell death and pathologies including auto-immune reactions, cancer, diabetes and neurodegeneration. Caenorhabditis elegans is an important genetic model organism both to find new drug-targets against parasitic nematodes and to study the conserved roles of sphingolipids in animals like their essential functions in very basic cellular processes ranging from maintenance of cell polarity and mitochondrial repair to growth and survival. C. elegans produces sphingoid bases which are structurally distinct from those of other animals as both iso- and anteiso-branched species have been re

SUBMITTER: Hannich JT 

PROVIDER: S-EPMC6094178 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature