Epigenetic Aging in Major Depressive Disorder.

ABSTRACT:

Objective

Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue.

Method

DNAm age was estimated using all methylation sites in blood of 811 depressed patients and 319 control subjects with no lifetime psychiatric disorders and low depressive symptoms from the Netherlands Study of Depression and Anxiety. The residuals of the DNAm age estimates regressed on chronological age were calculated to indicate epigenetic aging. Major depression diagno

SUBMITTER: Han LKM 

PROVIDER: S-EPMC6094380 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature