Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC6094396 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20180615 8
Cpf1 has been harnessed as a tool for genome manipulation in various species because of its simplicity and high efficiency. Our recent study demonstrated that FnCpf1 could be utilized for human genome editing with notable advantages for target sequence selection due to the flexibility of the protospacer adjacent motif (PAM) sequence. Multiplex genome editing provides a powerful tool for targeting members of multigene families, dissecting gene networks, modeling multigenic disorders in vivo, and ...[more]