Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients.

ABSTRACT:

Background

Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients.

Methods

Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10^- 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used.

Results

In total, 9 GWASs were

SUBMITTER: Mahmoudpour SH 

PROVIDER: S-EPMC6094450 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature