Systems level expression correlation of Ras GTPase regulators.

ABSTRACT:

Background

Proteins of the ubiquitously expressed core proteome are quantitatively correlated across multiple eukaryotic species. In addition, it was found that many protein paralogues exhibit expression anticorrelation, suggesting that the total level of protein with a given functionality must be kept constant.

Methods

We performed Spearman's rank correlation analyses of gene expression levels for the RAS GTPase subfamily and their regulatory GEF and GAP proteins across tissues and across individuals for each tissue. A large set of published data for normal tissues from a wide range of species, human cancer tissues and human cell lines was analysed.

Results

We show that although the multidomain regulatory proteins of Ras GTPases exhibit considerable tissue and indivi

SUBMITTER: Besray Unal E 

PROVIDER: S-EPMC6094892 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature