Impact of non-LTR retrotransposons in the differentiation and evolution of anatomically modern humans.

ABSTRACT:

Background

Transposable elements are biologically important components of eukaryote genomes. In particular, non-LTR retrotransposons (N-LTRrs) played a key role in shaping the human genome throughout evolution. In this study, we compared retrotransposon insertions differentially present in the genomes of Anatomically Modern Humans, Neanderthals, Denisovans and Chimpanzees, in order to assess the possible impact of retrotransposition in the differentiation of the human lineage.

Results

We first identified species-specific N-LTRrs and established their distribution in present day human populations. These analyses shortlisted a group of N-LTRr insertions that were found exclusively in Anatomically Modern Humans. These insertions are associated with an increase in the number of

SUBMITTER: Guichard E 

PROVIDER: S-EPMC6094920 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature