Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex.

ABSTRACT:

Background

Prenatal ambient fine particulate matter (PM_2.5) and maternal chronic psychosocial stress have independently been linked to changes in mithochondrial DNA copy number (mtDNAcn), a marker of mitochondrial response and dysfunction. Further, overlapping research shows sex-specific effects of PM_2.5 and stress on developmental outcomes. Interactions among PM_2.5, maternal stress, and child sex have not been examined in this context.

Methods

We examined associations among exposure to prenatal PM_2.5, maternal lifetime traumatic stressors, and mtDNAcn at birth in a sociodemographically diverse pregnancy cohort (N=167). Mothers' daily exposure to PM_2.5 over gestation was estimated using a satellite-based spatio-temporall

SUBMITTER: Brunst KJ 

PROVIDER: S-EPMC6094933 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature