Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila.

ABSTRACT: Among the major challenges in quantitative genetics and personalized medicine is to understand how gene × gene interactions (G × G: epistasis) and gene × environment interactions (G × E) underlie phenotypic variation. Here, we use the intimate relationship between mitochondria and oxygen availability to dissect the roles of nuclear DNA (nDNA) variation, mitochondrial DNA (mtDNA) variation, hypoxia, and their interactions on gene expression in Drosophila melanogaster. Mitochondria provide an important evolutionary and medical context for understanding G × G and G × E given their central role in integrating cellular signals. We hypothesized that hypoxia would alter mitonuclear communication and gene expression patterns. We show that first order nDNA, mtDNA, and hypoxia effects vary between t

SUBMITTER: Mossman JA 

PROVIDER: S-EPMC6095086 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature