Strong correlation of lumefantrine concentrations in capillary and venous plasma from malaria patients.

ABSTRACT:

Background

Lumefantrine is a long-acting antimalarial drug with an elimination half-life of over 3 days and protein binding of 99 percent. Correlation of lumefantrine concentrations from capillary plasma via fingerprick (Cc) versus venous plasma (Cv) remains to be defined.

Methods

Venous and capillary plasma samples were collected simultaneously from children, pregnant women, and non-pregnant adults at 2, 24, 120hr post last dose of a standard 3-day artemether-lumefantrine regimen they received for uncomplicated malaria. Some of the enrolled children and pregnant women were also HIV-infected. Samples were analyzed via liquid chromatography tandem mass spectrometry. Linear regression analysis was performed using the program Stata® SE12.1.

Results

In children, the linea

SUBMITTER: Huang L 

PROVIDER: S-EPMC6095545 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature